| Type of car | CC | HP | KW | Body | Technical information | From year... | ...to year | 
| S 280 (221.054) | 2996 | 231 | 170 | Saloon | - Engine type - Petrol Engine
 - Engine code - M 272.946
 - Number of cylinders - 6
 - Valves per cylinder - 4
 - Fuel - Petrol
 - Drive type - Rear Wheel Drive
 - Refueling - Intake Manifold Injection/ Carburettor
 
  | 08/2006 |   | 
| S 300 (221.054) | 2996 | 231 | 170 | Saloon | - Engine type - Petrol Engine
 - Engine code - M 272.946
 - Number of cylinders - 6
 - Valves per cylinder - 4
 - Fuel - Petrol
 - Drive type - Rear Wheel Drive
 - Refueling - Intake Manifold Injection/ Carburettor
 
  | 08/2006 |   | 
| S 350 (221.056, 221.156) | 3498 | 272 | 200 | Saloon | - Engine type - Petrol Engine
 - Engine code - M 272.965
 - Number of cylinders - 6
 - Valves per cylinder - 4
 - Fuel - Petrol
 - Drive type - Rear Wheel Drive
 - Refueling - Intake Manifold Injection/ Carburettor
 
  | 10/2005 |   | 
| S 350 4-matic (221.087, 221.187) | 3498 | 272 | 200 | Saloon | - Engine type - Petrol Engine
 - Engine code - M 272.975
 - Number of cylinders - 6
 - Valves per cylinder - 4
 - Fuel - Petrol
 - Drive type - All-wheel Drive
 - Refueling - Intake Manifold Injection/ Carburettor
 
  | 02/2008 |   | 
| S 350 CGI (221.057, 221.157) | 3498 | 306 | 225 | Saloon | - Engine type - Petrol Engine
 - Engine code - M 276.950
 - Number of cylinders - 6
 - Valves per cylinder - 4
 - Fuel - Petrol
 - Drive type - Rear Wheel Drive
 - Refueling - Direct Injection
 
  | 04/2011 |   | 
| S 350 CGI 4-matic (221.082, 221.182) | 3498 | 306 | 225 | Saloon | - Engine type - Petrol Engine
 - Engine code - M 276.950
 - Number of cylinders - 6
 - Valves per cylinder - 4
 - Fuel - Petrol
 - Drive type - All-wheel Drive
 - Refueling - Direct Injection
 
  | 04/2011 |   | 
| S 400 Hybrid (221.095, 221.195) | 3498 | 279 | 205 | Saloon | - Engine type - Hybrid
 - Engine code - M 272.974
 - Number of cylinders - 6
 - Valves per cylinder - 4
 - Fuel - Petrol/Electro
 - Drive type - Rear Wheel Drive
 - Refueling - Intake Manifold Injection/ Carburettor
 
  | 01/2009 |   | 
| S 450 (221.070, 221.170) | 4663 | 340 | 250 | Saloon | - Engine type - Petrol Engine
 - Engine code - M 273.922
 - Number of cylinders - 8
 - Valves per cylinder - 4
 - Fuel - Petrol
 - Drive type - Rear Wheel Drive
 - Refueling - Intake Manifold Injection/ Carburettor
 
  | 12/2005 |   | 
| S 450 4-matic (221.084, 221.184) | 4663 | 340 | 250 | Saloon | - Engine type - Petrol Engine
 - Engine code - M 273.924
 - Number of cylinders - 8
 - Valves per cylinder - 4
 - Fuel - Petrol
 - Drive type - All-wheel Drive
 - Refueling - Intake Manifold Injection/ Carburettor
 
  | 12/2005 |   | 
| S 500 CGI (221.073, 221.173) | 4663 | 435 | 320 | Saloon | - Engine type - Petrol Engine
 - Engine code - M 278.932
 - Number of cylinders - 8
 - Valves per cylinder - 4
 - Fuel - Petrol
 - Drive type - Rear Wheel Drive
 - Refueling - Direct Injection
 
  | 04/2011 |   | 
| S 500 CGI  4-matic (221.094, 221.194) | 4663 | 435 | 320 | Saloon | - Engine type - Petrol Engine
 - Engine code - M 278.932
 - Number of cylinders - 8
 - Valves per cylinder - 4
 - Fuel - Petrol
 - Drive type - All-wheel Drive
 - Refueling - Direct Injection
 
  | 03/2011 |   | 
| S 500 (221.071, 221.171) | 5461 | 388 | 285 | Saloon | - Engine type - Petrol Engine
 - Engine code - M 273.961
 - Number of cylinders - 8
 - Valves per cylinder - 4
 - Fuel - Petrol
 - Drive type - Rear Wheel Drive
 - Refueling - Intake Manifold Injection/ Carburettor
 
  | 10/2005 |   | 
| S 500 4-matic (221.086, 221.186) | 5461 | 388 | 285 | Saloon | - Engine type - Petrol Engine
 - Engine code - M 273.961, M 273.968
 - Number of cylinders - 8
 - Valves per cylinder - 4
 - Fuel - Petrol
 - Drive type - All-wheel Drive
 - Refueling - Intake Manifold Injection/ Carburettor
 
  | 10/2005 |   | 
| S 600 (221.176) | 5513 | 517 | 380 | Saloon | - Engine type - Petrol Engine
 - Engine code - M 275.953
 - Number of cylinders - 12
 - Valves per cylinder - 3
 - Fuel - Petrol
 - Drive type - Rear Wheel Drive
 - Refueling - Intake Manifold Injection/ Carburettor
 
  | 12/2005 |   | 
| S 63 AMG (221.077, 221.177) | 6208 | 525 | 386 | Saloon | - Engine type - Petrol Engine
 - Engine code - M 156.984
 - Number of cylinders - 8
 - Valves per cylinder - 4
 - Fuel - Petrol
 - Drive type - Rear Wheel Drive
 - Refueling - Intake Manifold Injection/ Carburettor
 
  | 10/2006 |   | 
| S 63 AMG (221.074, 221.174) | 5461 | 544 | 400 | Saloon | - Engine type - Petrol Engine
 - Engine code - M 157.980
 - Number of cylinders - 8
 - Valves per cylinder - 4
 - Fuel - Petrol
 - Drive type - Rear Wheel Drive
 - Refueling - Direct Injection
 
  | 03/2011 |   | 
| S 63 AMG (221.074, 221.174) | 5461 | 571 | 420 | Saloon | - Engine type - Petrol Engine
 - Engine code - M 157.980
 - Number of cylinders - 8
 - Valves per cylinder - 4
 - Fuel - Petrol
 - Drive type - Rear Wheel Drive
 - Refueling - Direct Injection
 
  | 02/2012 |   | 
| S 65 AMG (221.179) | 5980 | 612 | 450 | Saloon | - Engine type - Petrol Engine
 - Engine code - M 275.982
 - Number of cylinders - 12
 - Valves per cylinder - 3
 - Fuel - Petrol
 - Drive type - Rear Wheel Drive
 - Refueling - Intake Manifold Injection/ Carburettor
 
  | 12/2005 |   | 
| S 65 AMG (221.179) | 5980 | 630 | 463 | Saloon | - Engine type - Petrol Engine
 - Engine code - M 275.982
 - Number of cylinders - 12
 - Valves per cylinder - 3
 - Fuel - Petrol
 - Drive type - Rear Wheel Drive
 - Refueling - Intake Manifold Injection/ Carburettor
 
  | 04/2011 |   | 
| S 250 CDI (221.003, 221.103) | 2143 | 204 | 150 | Saloon | - Engine type - Diesel
 - Engine code - OM 651.961
 - Number of cylinders - 4
 - Valves per cylinder - 4
 - Fuel - Diesel
 - Drive type - Rear Wheel Drive
 - Refueling - Direct Injection
 
  | 01/2011 |   | 
| S 320 CDI 4-matic (221.080, 221.180) | 2987 | 211 | 155 | Saloon | - Engine type - Diesel
 - Engine code - OM 642.932
 - Number of cylinders - 6
 - Valves per cylinder - 4
 - Fuel - Diesel
 - Drive type - All-wheel Drive
 - Refueling - Direct Injection
 
  | 10/2005 |   | 
| S 320 CDI (221.022, 221.122) | 2987 | 235 | 173 | Saloon | - Engine type - Diesel
 - Engine code - OM 642.930
 - Number of cylinders - 6
 - Valves per cylinder - 4
 - Fuel - Diesel
 - Drive type - Rear Wheel Drive
 - Refueling - Direct Injection
 
  | 12/2005 | 06/2009 | 
| S 350 CDI | 2987 | 235 | 173 | Saloon | - Engine type - Diesel
 - Engine code - OM 642.930
 - Number of cylinders - 6
 - Valves per cylinder - 4
 - Fuel - Diesel
 - Drive type - Rear Wheel Drive
 - Refueling - Direct Injection
 
  | 06/2009 |   | 
| S 320 CDI 4-matic (221.080, 221.180) | 2987 | 235 | 173 | Saloon | - Engine type - Diesel
 - Engine code - OM 642.932
 - Number of cylinders - 6
 - Valves per cylinder - 4
 - Fuel - Diesel
 - Drive type - All-wheel Drive
 - Refueling - Direct Injection
 
  | 10/2006 |   | 
| S 350 BlueTec (221.026, 221.126) | 2987 | 258 | 190 | Saloon | - Engine type - Diesel
 - Engine code - OM 642.862
 - Number of cylinders - 6
 - Valves per cylinder - 4
 - Fuel - Diesel
 - Drive type - Rear Wheel Drive
 - Refueling - Direct Injection
 
  | 04/2011 |   | 
| S 350 BlueTEC 4-matic (221.083, 221.183) | 2987 | 258 | 190 | Saloon | - Engine type - Diesel
 - Engine code - OM 642.868
 - Number of cylinders - 6
 - Valves per cylinder - 4
 - Fuel - Diesel
 - Drive type - All-wheel Drive
 - Refueling - Direct Injection
 
  | 04/2011 |   | 
| S 420 CDI / S 450 CDI (221.028, 221.128) | 3996 | 320 | 235 | Saloon | - Engine type - Diesel
 - Engine code - OM 629.911
 - Number of cylinders - 8
 - Valves per cylinder - 4
 - Fuel - Diesel
 - Drive type - Rear Wheel Drive
 - Refueling - Direct Injection
 
  | 10/2006 |   |